Cyclin D3 Antikörper

Produktnummer ABIN6566666

Der Kaninchen Polyklonal anti-Cyclin D3 Antikörper wird verwendet zum Nachweis von Cyclin D3 in Proben von Human und Maus. Er wurde validiert für WB.

Kurzübersicht für Cyclin D3 Antikörper (ABIN6566666)

Target: Cyclin D3 (CCND3)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin D3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Güteklasse: KO Validated

Produktdetails anti-Cyclin D3 Antikörper

Spezifität: This antibody ist KO validated.

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human CCND3 (NP_001751.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Cyclin D3

Target: Cyclin D3 (CCND3)

Andere Bezeichnung: CCND3

Hintergrund: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht:

Observed_MW: 36kDa

Calculated_MW: 9kDa/22kDa/24kDa/32kDa

Gen-ID: 896

UniProt: P30281

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, Glycosaminoglycan Metabolic Process