MECP2 Antikörper

Produktnummer ABIN6566655

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MECP2 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für MECP2 Antikörper (ABIN6566655)

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MECP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-MECP2 Antikörper

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human MECP2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:1000 IHC 1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu MECP2

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Andere Bezeichnung: MECP2

Hintergrund:

Synonyms: AUTSX 3,AUTSX3,DKFZp686A24160,Mbd 5,Mbd5,MECP 2,MeCP 2 protein,MeCP-2 protein,Mecp2,MECP2,Methyl CpG binding protein 2 (Rett syndrome),Methyl CpG binding protein 2,Methyl-CpG-binding protein 2,MRX 16,MRX 79,MRX16,MRX79,MRXS 13,MRXS13,MRXSL,PPMX,RS,RTS,RTT,WBP 10,WBP10

Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht:

Observed_MW: 83kDa

Calculated_MW: 52kDa/53kDa

Gen-ID: 4204

UniProt: P51608

Pathways: Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane