Sphingosine Kinase 1 (SPHK1) Antikörper

Details zu Produkt Nr. ABIN6566633
Target
Reaktivität
Human, Maus
126
53
47
12
3
2
2
2
1
1
1
1
1
1
Wirt
Kaninchen
114
8
7
Klonalität
Polyklonal
Konjugat
Unkonjugiert
9
7
5
5
5
5
4
4
3
3
3
3
1
1
1
1
1
Applikation
Immunofluorescence (IF), Western Blotting (WB)
93
54
38
18
16
13
10
7
5
3
3
2
1
Optionen
Immunogen Recombinant protein of human SPHK1
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung SPHK1 (SPHK1 Antibody Abstract)
Hintergrund

Synonyms: SK 1,SK1,Sphingosine kinase 1,SPHK 1,SPHK,Sphk1,SPHK1,SPK ,SPK 1

Background: The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht

Observed_MW: 60kDa

Calculated_MW: 42kDa/43kDa/51kDa

Gen-ID 8877
UniProt Q9NYA1
Pathways VEGF Signaling
Applikations-hinweise WB 1:500 - 1:2000 IF 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Sphingosine Kinase 1 (SPHK1) antibody (ABIN6566633) Western blot analysis of extracts of various cell lines, using SPHK1 antibody.
Image no. 2 for anti-Sphingosine Kinase 1 (SPHK1) antibody (ABIN6566633) Immunofluorescence analysis of HeLa cells using SPHK1 antibody.