XRCC6 Antikörper

Produktnummer ABIN6296746

Dieser Maus Monoklonal Antikörper detektiert spezifisch XRCC6 in IF, FACS und ICC. Es zeigt Reaktivität gegenüber Proben von Human und Primate.

Kurzübersicht für XRCC6 Antikörper (ABIN6296746)

Target: XRCC6 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6))

Reaktivität: Human, Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser XRCC6 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Produktdetails anti-XRCC6 Antikörper

Verwendungszweck: Mouse anti-Human/Primates Ku70 + Ku80 Antibody [Sodium Azide Free]

Spezifität: Nuclear

Aufreinigung: Nuclear extract of human HL-60 cells was used as the immunogen for this Ku70 + Ku80 antibody.

Immunogen: Nuclear extract of human HL-60 cells was used as the immunogen for this Ku70 + Ku80 antibody.

Anwendungsinformationen

Applikationshinweise: Flow cytometry: 0.5-1 μg/10e6 cells
IF: 0.5-1.0 μg/mL
Immunocytochemistry (Acetone-fixed cells): 0.25-0.5 μg/mL for 30 minutes at RT

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu XRCC6

Target: XRCC6 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6))

Andere Bezeichnung: X-ray repair cross-complementing protein 6

Hintergrund:

Target Description: This antibody recognizes a dimer of two proteins of 70 kDa (Ku70) and ~80 kDa (Ku80), identified as two subunits of Ku. Antbody KU729 recognizes a conformational epitope of the Ku70 + Ku80 dimer, which is destroyed during Western blotting. The Ku70 + Ku80 dimer is important for function of a 460 kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.

Gene Symbol: XRCC6///G22P1

Gen-ID: 2547

UniProt: P12956

Pathways: DNA Reparatur