XRCC6 Antikörper (AA 408-609)

Produktnummer ABIN6150312

Produktdetails anti-XRCC6 Antikörper

Target: XRCC6 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6))

Bindungsspezifität: AA 408-609

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XRCC6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Sequenz: PYFVALVPQE EELDDQKIQV TPPGFQLVFL PFADDKRKMP FTEKIMATPE QVGKMKAIVE KLRFTYRSDS FENPVLQQHF RNLEALALDL MEPEQAVDLT LPKVEAMNKR LGSLVDEFKE LVYPPDYNPE GKVTKRKHDN EGSGSKRPKV EYSEEELKTH ISKGTLGKFT VPMLKEACRA YGLKSGLKKQ ELLEALTKHF QD

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 408-609 of human Ku70 (NP_001460.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:100,IP,1:20 - 1:50

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-XRCC6 Antikörper (ABIN6150312)

Zhang, Chang, Sun, Chen, Yang, Tang, Jing, Kang, He, Wu, Wei, Wang, Xu, Zhu, Shen, Zeng, Wang, Liu, Zhang, Mao, Jiang, Sun: "Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability." in: Journal of cell science, Vol. 131, Issue 12, (2018) (PubMed).

Details zu XRCC6

Target: XRCC6 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6))

Andere Bezeichnung: XRCC6 (XRCC6 Produkte)

Synonyme: CTC75 antikoerper, CTCBF antikoerper, G22P1 antikoerper, KU70 antikoerper, ML8 antikoerper, TLAA antikoerper, 70kDa antikoerper, G22p1 antikoerper, Ku70 antikoerper, Kup70 antikoerper, X-ray repair cross complementing 6 antikoerper, ATP-dependent DNA helicase II, 70 kDa subunit antikoerper, X-ray repair complementing defective repair in Chinese hamster cells 6 L homeolog antikoerper, X-ray repair complementing defective repair in Chinese hamster cells 6 antikoerper, XRCC6 antikoerper, Bm1_41430 antikoerper, xrcc6.L antikoerper, Xrcc6 antikoerper

Hintergrund: The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.,XRCC6,CTC75,CTCBF,G22P1,KU70,ML8,TLAA,Epigenetics & Nuclear Signaling,DNA Damage & Repair,RNA Binding,Cancer,Cell Biology & Developmental Biology,Cell Cycle,XRCC6

Molekulargewicht: 65 kDa/69 kDa

Gen-ID: 2547

UniProt: P12956

Pathways: DNA Reparatur