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E2F1 Antikörper (C-Term)

This anti-E2F1 antibody (ABIN6266337) is a Rabbit Polyclonal antibody detecting E2F1 in WB, ELISA, IHC. Suitable for Human, Mouse, Rat.
Produktnummer ABIN6266337

Kurzübersicht für E2F1 Antikörper (C-Term) (ABIN6266337)

Target

Alle E2F1 Antikörper anzeigen
E2F1 (E2F Transcription Factor 1 (E2F1))

Reaktivität

  • 204
  • 101
  • 55
  • 6
  • 6
  • 6
  • 5
  • 5
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 206
  • 14
  • 2
Kaninchen

Klonalität

  • 193
  • 29
Polyklonal

Konjugat

  • 102
  • 15
  • 14
  • 11
  • 8
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser E2F1 Antikörper ist unkonjugiert

Applikation

  • 187
  • 93
  • 66
  • 66
  • 51
  • 28
  • 27
  • 23
  • 19
  • 19
  • 17
  • 17
  • 6
  • 2
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 25
    • 24
    • 19
    • 15
    • 15
    • 9
    • 8
    • 8
    • 8
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    E2F1 Antibody detects endogenous levels of total E2F1.

    Homologie

    Pig,Bovine,Horse,Rabbit

    Aufreinigung

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human E2F1, corresponding to a region within C-terminal amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Target

    E2F1 (E2F Transcription Factor 1 (E2F1))

    Andere Bezeichnung

    E2F1

    Hintergrund

    Description: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Positively regulates transcription of RRP1B (PubMed:20040599).

    Gene: E2F1

    Molekulargewicht

    47kDa

    Gen-ID

    1869

    UniProt

    Q01094

    Pathways

    p53 Signalweg, Zellzyklus, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Autophagie
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