EPAS1 Antikörper (Internal Region)
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- Target Alle EPAS1 Antikörper anzeigen
- EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Ratte, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser EPAS1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
- Spezifität
- HIF-2-alpha Antibody detects endogenous levels of total HIF-2-alpha.
- Homologie
- Pig,Bovine,Horse,Rabbit,Dog,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human HIF-2-alpha, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product EPAS1 Primärantikörper
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anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 339-541) antibody
EPAS1 Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 21-336) antibodyEPAS1 Reaktivität: Maus WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (Ser343) antibodyEPAS1 Reaktivität: Human, Ratte, Maus WB, ELISA, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 680-870) antibodyEPAS1 Reaktivität: Human IHC, ELISA, ICC, FACS Wirt: Maus Monoclonal 1H3E12 unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (C-Term) antibodyEPAS1 Reaktivität: Human, Ratte, Maus, Fisch WB, IHC, ELISA, IP, ICC, FACS, IF, ChIP, GS Wirt: Kaninchen Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 28-347) antibodyEPAS1 Reaktivität: Human WB, ELISA, IF Wirt: Maus Monoclonal 1G2 unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) antibodyEPAS1 Reaktivität: Human WB, ChIP Wirt: Kaninchen Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 588-870) antibodyEPAS1 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 535-631) antibodyEPAS1 Reaktivität: Human, Ratte, Maus, Hamster WB, IHC, ELISA, IP, ICC, FACS, IF, ChIP Wirt: Maus Monoclonal ep190b unconjugated
anti-Endothelial PAS Domain Protein 1 (EPAS1) (AA 1-130) antibodyEPAS1 Reaktivität: Human, Ratte, Maus, Affe, Schaf WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- WB 1:1000-3000, IF/ICC, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
- Andere Bezeichnung
- EPAS1 (EPAS1 Produkte)
- Hintergrund
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Description: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
Gene: EPAS1
- Molekulargewicht
- 96kDa
- Gen-ID
- 2034
- UniProt
- Q99814
- Pathways
- Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effekt
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