FZD7 Antikörper (C-Term)

Produktnummer ABIN6261841

Produktdetails anti-FZD7 Antikörper

Target: FZD7 (Frizzled Family Receptor 7 (FZD7))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FZD7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: FZD7 Antibody detects endogenous levels of total FZD7.

Homologie: Pig,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human FZD7, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu FZD7

Target: FZD7 (Frizzled Family Receptor 7 (FZD7))

Andere Bezeichnung: FZD7 (FZD7 Produkte)

Synonyme: FzE3 antikoerper, Fz-7 antikoerper, Xfz7 antikoerper, frizzled-7 antikoerper, frizzled7 antikoerper, frz-7 antikoerper, frz7 antikoerper, fz7 antikoerper, fzd7-a antikoerper, fzd7-b antikoerper, fze3 antikoerper, Fz7 antikoerper, cFz-7 antikoerper, fb38g02 antikoerper, fc44b09 antikoerper, fz13 antikoerper, fz7a antikoerper, fz7b antikoerper, wu:fb38g02 antikoerper, wu:fc44b09 antikoerper, zg13 antikoerper, frizzled class receptor 7 antikoerper, frizzled class receptor 7 L homeolog antikoerper, frizzled class receptor 7b antikoerper, FZD7 antikoerper, fzd7.L antikoerper, fzd7 antikoerper, Fzd7 antikoerper, fzd7b antikoerper

Hintergrund:

Description: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Gene: FZD7

Molekulargewicht: 63 kDa

Gen-ID: 8324

UniProt: O75084

Pathways: WNT Signalweg, Stem Cell Maintenance