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RGS14 Antikörper (Regulator of G-Protein Signaling 14) Primary Antibody

RGS14 Reaktivität: Human, Maus, Ratte ELISA, ICC, IF, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6258314
$390.77
Zzgl. Versandkosten $45.00
100 μL ABIN6258314
100 μL ABIN6258314
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 8 bis 9 Werktagen
  • Target
    RGS14
    Reaktivität
    Human, Maus, Ratte
    • 54
    • 17
    • 10
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Wirt
    Kaninchen
    • 43
    • 7
    • 4
    • 1
    Klonalität
    Polyklonal
    • 53
    • 2
    Konjugat
    Dieser RGS14 Antikörper ist unkonjugiert
    • 28
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Applikation
    ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
    • 47
    • 31
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Spezifität
    RGS14 Antibody detects endogenous levels of total RGS14
    Kreuzreaktivität
    Human, Maus, Ratte (Rattus)
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:500~1:1000, IF/ICC 1:100-1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C.Stable for 12 months from date of receipt
    Haltbarkeit
    12 months
  • Target
    RGS14
    Andere Bezeichnung
    RGS14 (RGS14 Antibody Abstract)
    Synonyme
    RPIP1, MGC80558, RGS14, rgs14, wu:fi04g12, regulator of G protein signaling 14, regulator of G-protein signaling 14, regulator of G-protein signaling 14 L homeolog, regulator of G-protein signalling 14, regulator of G protein signaling 14a, RGS14, Rgs14, rgs14.L, rgs14, rgs14a
    Hintergrund

    Description: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation, a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory.

    Gene: RGS14

    Molekulargewicht
    65 kDa
    Gen-ID
    10636
    UniProt
    O43566
    Pathways
    Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Platelet-derived growth Factor Receptor Signaling
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