PFKL Antikörper (C-Term)
Kurzübersicht für PFKL Antikörper (C-Term) (ABIN6257021)
Target
Alle PFKL Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- C-Term
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Spezifität
- K6PL Antibody detects endogenous levels of total K6PL.
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Homologie
- Pig,Bovine,Horse,Sheep,Dog,Chicken
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Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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Immunogen
- A synthesized peptide derived from human K6PL, corresponding to a region within C-terminal amino acids.
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Isotyp
- IgG
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Applikationshinweise
- WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
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Haltbarkeit
- 12 months
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- PFKL (Phosphofructokinase, Liver (PFKL))
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Andere Bezeichnung
- PFKL
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Hintergrund
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Description: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity).
Gene: PFKL
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Molekulargewicht
- 85 kDa
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Gen-ID
- 5211
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UniProt
- P17858
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Pathways
- Negative Regulation of Hormone Secretion, Warburg Effekt
Target
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