Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

GATA4 Antikörper (pSer262)

Der Kaninchen Polyklonal Anti-GATA4-Antikörper wurde für WB, ELISA, IHC, IF und ICC validiert. Er ist geeignet, GATA4 in Proben von Human, Ratte und Maus zu detektieren.
Produktnummer ABIN6256227

Kurzübersicht für GATA4 Antikörper (pSer262) (ABIN6256227)

Target

Alle GATA4 Antikörper anzeigen
GATA4 (GATA Binding Protein 4 (GATA4))

Reaktivität

  • 85
  • 57
  • 56
  • 6
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Ratte, Maus

Wirt

  • 75
  • 11
  • 1
Kaninchen

Klonalität

  • 65
  • 22
Polyklonal

Konjugat

  • 60
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser GATA4 Antikörper ist unkonjugiert

Applikation

  • 70
  • 30
  • 22
  • 19
  • 13
  • 13
  • 10
  • 8
  • 7
  • 4
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 15
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer262

    Spezifität

    Phospho-GATA4 (Ser262) Antibody detects endogenous levels of GATA4 only when phosphorylated at Serine 262.

    Homologie

    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

    Aufreinigung

    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

    Immunogen

    A synthesized peptide derived from human GATA4 around the phosphorylation site of Ser262.

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:500, ELISA(peptide) 1:20000-1:40000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Target

    GATA4 (GATA Binding Protein 4 (GATA4))

    Andere Bezeichnung

    GATA4

    Hintergrund

    Description: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735).

    Gene: GATA4

    Molekulargewicht

    48kDa

    Gen-ID

    2626

    UniProt

    P43694

    Pathways

    Peptide Hormone Metabolism, Carbohydrate Homeostasis
Sie sind hier:
Chat with us!