RIPK3 Antikörper

Produktnummer ABIN6243991

Der Maus Monoklonal anti-RIPK3 Antikörper (Klon 2013CT892-86-49) (ABIN6243991) detektiert spezifisch RIPK3 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für RIPK3 Antikörper (ABIN6243991)

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RIPK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 2013CT892-86-49

Produktdetails anti-RIPK3 Antikörper

Homologie: H

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This RIPK3 antibody is generated from a mouse immunized with a recombinate protein from the human region of human RIPK3.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu RIPK3

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Andere Bezeichnung: RIPK3

Hintergrund: Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Molekulargewicht: 56887

UniProt: Q9Y572

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades