WWTR1 Antikörper (C-Term)

Produktnummer ABIN6243336

This anti-WWTR1 antibody (ABIN6243336) is a Rabbit Polyclonal antibody detecting WWTR1 in WB. Suitable for Human.

Kurzübersicht für WWTR1 Antikörper (C-Term) (ABIN6243336)

Target: WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WWTR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB51589

Produktdetails anti-WWTR1 Antikörper

Bindungsspezifität: AA 296-330, C-Term

Homologie: M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This WWTR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 296-330 amino acids from the C-terminal region of human WWTR1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu WWTR1

Target: WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Andere Bezeichnung: WWTR1

Hintergrund: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

Molekulargewicht: 44101

UniProt: Q9GZV5

Pathways: Regulation of Lipid Metabolism by PPARalpha