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WWTR1 Antikörper (AA 1-230)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch WWTR1 in WB, IHC und IF. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN6150278

Kurzübersicht für WWTR1 Antikörper (AA 1-230) (ABIN6150278)

Target

Alle WWTR1 Antikörper anzeigen
WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Reaktivität

  • 34
  • 8
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 29
  • 5
Kaninchen

Klonalität

  • 29
  • 5
Polyklonal

Konjugat

  • 24
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser WWTR1 Antikörper ist unkonjugiert

Applikation

  • 27
  • 12
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
  • Bindungsspezifität

    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-230

    Sequenz

    MNPASAPPPL PPPGQQVIHV TQDLDTDLEA LFNSVMNPKP SSWRKKILPE SFFKEPDSGS HSRQSSTDSS GGHPGPRLAG GAQHVRSHSS PASLQLGTGA GAAGSPAQQH AHLRQQSYDV TDELPLPPGW EMTFTATGQR YFLNHIEKIT TWQDPRKAMN QPLNHMNLHP AVSSTPVPQR SMAVSQPNLV MNHQHQQQMA PSTLSQQNHP TQNPPAGLMS MPNALTTQQQ

    Kreuzreaktivität

    Human, Maus, Ratte

    Produktmerkmale

    Polyclonal Antibodies

    Immunogen

    Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human TAZ (NP_056287.1).

    Isotyp

    IgG
  • Applikationshinweise

    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

    Kommentare

    HIGH QUALITY

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

    Andere Bezeichnung

    WWTR1

    Hintergrund

    Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.,WW domain-containing transcription regulator protein 1,Transcriptional coactivator with PDZ-binding motif,TAZ,WWTR1,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Hippo Signaling Pathway,Stem Cells,Mesenchymal Stem Cells,WWTR1

    Molekulargewicht

    44 kDa

    Gen-ID

    25937

    UniProt

    Q9GZV5

    Pathways

    Regulation of Lipid Metabolism by PPARalpha
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