TGFB1 Antikörper (AA 30-280)

Produktnummer ABIN6149071

Der Kaninchen Polyklonal Anti-TGFB1-Antikörper wurde für WB, IHC und IF validiert. Er ist geeignet, TGFB1 in Proben von Human zu detektieren. Es sind 7+ Publikationen verfügbar.

Kurzübersicht für TGFB1 Antikörper (AA 30-280) (ABIN6149071)

Target: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TGFB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-TGFB1 Antikörper

Bindungsspezifität: AA 30-280

Sequenz: LSTCKTIDME LVKRKRIEAI RGQILSKLRL ASPPSQGEVP PGPLPEAVLA LYNSTRDRVA GESAEPEPEP EADYYAKEVT RVLMVETHNE IYDKFKQSTH SIYMFFNTSE LREAVPEPVL LSRAELRLLR LKLKVEQHVE LYQKYSNNSW RYLSNRLLAP SDSPEWLSFD VTGVVRQWLS RGGEIEGFRL SAHCSCDSRD NTLQVDINGF TTGRRGDLAT IHGMNRPFLL LMATPLERAQ HLQSSRHRRA L

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-280 of human TGFB1 (NP_000651.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-TGFB1 Antikörper (ABIN6149071)

Liu, Zhang, Su, Wang, Liu, Kong: "Effects of cholecalciferol cholesterol emulsion on renal fibrosis and aquaporin 2 and 4 in mice with unilateral ureteral obstruction." in: Biomedicine & pharmacotherapy, Vol. 102, pp. 633-638, (2018) (PubMed).

Xiong, Zhao, Lin, Yao, Huang, Yu, Dong, Xiao, Zhao, Cai et al.: "Phosphorylation of low density lipoprotein receptor-related protein 6 is involved in receptor for advanced glycation end product-mediated β-catenin stabilization in a toluene diisocyanate-induced ..." in: International immunopharmacology, Vol. 59, pp. 187-196, (2018) (PubMed).

Chen, Li: "Telbivudine attenuates UUO-induced renal fibrosis via TGF-β/Smad and NF-κB signaling." in: International immunopharmacology, Vol. 55, pp. 1-8, (2018) (PubMed).

Zhao, Yin, Li, Fan, Yang, Chen, Wang: "MiR-30c protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition in db/db mice." in: Aging cell, Vol. 16, Issue 2, pp. 387-400, (2017) (PubMed).

Xie, Chen, Hu, Pan, Wang, Li, Geng, Xu: "Premature senescence of cardiac fibroblasts and atrial fibrosis in patients with atrial fibrillation." in: Oncotarget, Vol. 8, Issue 35, pp. 57981-57990, (2017) (PubMed).

Rokade, Kishore, Madan: "Surfactant protein D regulates murine testicular immune milieu and sperm functions." in: American journal of reproductive immunology (New York, N.Y. : 1989), Vol. 77, Issue 3, (2017) (PubMed).

Nagaraja, Krishnamoorthy, Raviraj, Paramasivam, Nagarajan: "Effect of Trichostatin A on radiation induced epithelial-mesenchymal transition in A549 cells." in: Biochemical and biophysical research communications, Vol. 493, Issue 4, pp. 1534-1541, (2017) (PubMed).

Details zu TGFB1

Target: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Andere Bezeichnung: TGFB1

Hintergrund: This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.,TGFB1,CED,DPD1,LAP,TGFB,TGFbeta,TGF-β,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Growth factor,TGF-b-Smad Signaling Pathway,Wnt/β-Catenin Signaling Pathway,Endocrine & Metabolism,Stem Cells,Cardiovascular,Angiogenesis,Angiogenic growth factors,Hypoxia,Ligand,TGFB1

Molekulargewicht: 44 kDa

Gen-ID: 7040

UniProt: P01137

Pathways: EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagie, Cancer Immune Checkpoints