MECP2 Antikörper (AA 1-100)

Produktnummer ABIN6143680

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MECP2 in IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für MECP2 Antikörper (AA 1-100) (ABIN6143680)

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MECP2 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF)

Produktdetails anti-MECP2 Antikörper

Bindungsspezifität: AA 1-100

Sequenz: MVAGMLGLRE EKSEDQDLQG LKDKPLKFKK VKKDKKEEKE GKHEPVQPSA HHSAEPAEAG KAETSEGSGS APAVPEASAS PKQRRSIIRD RGPMYDDPTL

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MECP2 (NP_004983.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu MECP2

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Andere Bezeichnung: MECP2

Hintergrund: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isoforms.,MECP2,AUTSX3,MRX16,MRX79,MRXS13,MRXSL,PPMX,RS,RTS,RTT,Epigenetics & Nuclear Signaling,RNA Binding,Neuroscience,Neurodegenerative Diseases,MECP2

Molekulargewicht: 52 kDa/53 kDa

Gen-ID: 4204

UniProt: P51608

Pathways: Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane