Survivin Antikörper (AA 1-142)

Produktnummer ABIN6137562

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Survivin in WB und IHC. Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für Survivin Antikörper (AA 1-142) (ABIN6137562)

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Survivin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Survivin Antikörper

Bindungsspezifität: AA 1-142

Sequenz: MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK KKEFEETAEK VRRAIEQLAA MD

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human Survivin (NP_001159.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-Survivin Antikörper (ABIN6137562)

Jin, Zhu, Liang, Huang, Xie, Xiao, Ni, Liu: "Sodium selenate activated Wnt/β-catenin signaling and repressed amyloid-β formation in a triple transgenic mouse model of Alzheimer's disease." in: Experimental neurology, Vol. 297, pp. 36-49, (2017) (PubMed).

Ying, Zhu, Liang, Ma, Li: "GLP1 protects cardiomyocytes from palmitate-induced apoptosis via Akt/GSK3b/b-catenin pathway." in: Journal of molecular endocrinology, Vol. 55, Issue 3, pp. 245-62, (2016) (PubMed).

Details zu Survivin

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Andere Bezeichnung: BIRC5

Hintergrund: This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.,API4,EPR-1,BIRC5,Survivin,Cancer,Invasion and Metastasis,Cell Biology & Developmental Biology,Apoptosis,Death receptors & ligands,Cell Cycle,Centrosome,Centromere,Neuroscience,Cell Type Marker,Neurodegenerative Diseases,Astrocyte marker,BIRC5

Molekulargewicht: 8 kDa/13 kDa/15 kDa/16 kDa/18 kDa

Gen-ID: 332

UniProt: O15392

Pathways: Apoptose, Zellzyklus, Nuclear Hormone Receptor Binding