SHP1 Antikörper (Tyr536)

Produktnummer ABIN5957429

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SHP1 in WB, ELISA und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für SHP1 Antikörper (Tyr536) (ABIN5957429)

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SHP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-SHP1 Antikörper

Bindungsspezifität: Tyr536

Spezifität: 70Z-SHP,EC 3.1.3.48,HCP,HCPH,Hematopoietic cell phosphatase,Hematopoietic cell protein tyrosine phosphatase,Hematopoietic cell protein-tyrosine phosphatase,HPTP1C,Protein tyrosine phosphatase 1C,Protein tyrosine phosphatase non receptor type 6,Protein tyrosine phosphatase SHP1,Protein-tyrosine phosphatase 1C,protein-tyrosine phosphatase SHP 1,Protein-tyrosine phosphatase SHP-1,PTN6,PTP 1C,PTP-1C,PTP1C,Ptpn6,SH PTP 1,SH PTP1,SH-PTP1,SHP 1,SHP 1L,SHP1,SHP1L,tyrosine protein phosphatase non receptor type 6,Tyrosine-protein phosphatase non-receptor type 6

Aufreinigung: Affinity purification

Immunogen: Synthesized peptide derived from human SH-PTP1 around the non-phosphorylation site of Y536.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide,0.5 % BSA and 50 % glycerol  pH 7.4.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SHP1

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Andere Bezeichnung: SH-PTP1

Hintergrund: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Molekulargewicht: 68kDa

Gen-ID: 5777

UniProt: P29350

Pathways: JAK-STAT Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling