E2F1 Antikörper (Internal Region, Lys120)
Kurzübersicht für E2F1 Antikörper (Internal Region, Lys120) (ABIN571306)
Target
Alle E2F1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- Internal Region, Lys120
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Spezifität
- Reacts with human E2F-1 acK120 and acK125
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Kreuzreaktivität
- Maus
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Kreuzreaktivität (Details)
- May cross-react with E2F-1 from mouse and other species due to sequence homology
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Aufreinigung
- Antiserum
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Immunogen
- Synthetic peptide derived from internal domain of human E2F-1 protein containing acetyl lysine 120 and 125
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Isotyp
- IgG
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Applikationshinweise
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Working dilution: Optimal dilutions should be determined by the end user.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Must be reconstituted in distilled water.
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Lagerung
- 4 °C/-20 °C
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Informationen zur Lagerung
- Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
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Haltbarkeit
- 24 months
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- E2F1 (E2F Transcription Factor 1 (E2F1))
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Andere Bezeichnung
- Transcription Factor E2F1 (E2F-1)
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Hintergrund
- Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis.
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UniProt
- Q01094
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Pathways
- p53 Signalweg, Zellzyklus, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Autophagie
Target
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