ERK1 Antikörper

Produktnummer ABIN5702776

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ERK1 in WB, IHC, ELISA und IF. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte und Zebrafisch (Danio rerio).

Kurzübersicht für ERK1 Antikörper (ABIN5702776)

Target: ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-ERK1 Antikörper

Verwendungszweck: ERK1/2 antibody

Immunogen: mitogen-activated protein kinase 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB : 1:1000-1:10000 IHC : 1:50-1:200 IF : 1:10-1:100

Kommentare:

HeLa cells were subjected to SDS PAGE followed by western blot with FNab02845(ERK1/2 antibody) at dilution of 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu ERK1

Target: ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))

Andere Bezeichnung: ERK1

Hintergrund:

Synonyms: Mitogen-activated protein kinase 1 (MAP kinase 1, MAPK 1)|ERT1|Extracellular signal-regulated kinase 2 (ERK-2)|MAP kinase isoform p42 (p42-MAPK)|Mitogen-activated protein kinase 2 (MAP kinase 2, MAPK 2)|MAPK1|ERK2|PRKM1|PRKM2

Background: This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Molekulargewicht: 38-44 kDa

UniProt: P28482

Pathways: MAPK Signalweg, RTK Signalweg, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, S100 Proteine