MALT1 Antikörper (AA 630-680)

Produktnummer ABIN5690045

Dieser Anti-MALT1 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von MALT1 in WB, IF, ELISA und IHC (p). Geeignet für Human, Maus und Ratte.

Kurzübersicht für MALT1 Antikörper (AA 630-680) (ABIN5690045)

Target: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MALT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-MALT1 Antikörper

Bindungsspezifität: AA 630-680

Spezifität: MALT1 antibody is human, mouse and rat reactive. At least two isoforms of MALT1 are known to exist, this antibody will detect both isoforms.

Aufreinigung: MALT1 antibody is affinity chromatography purified via peptide column.

Immunogen: MALT1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MALT1.

The immunogen is located within amino acids 630 - 680 of MALT1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: MALT1 antibody can be used for detection of MALT1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: MALT1 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: MALT1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu MALT1

Target: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Andere Bezeichnung: MALT1

Hintergrund: MALT1 was initially identified as a novel gene that was recurrently rearranged in t(11,18)(q21,q21) mucosa-associated lymphoid tissue lymphomas along with the apoptosis inhibitor protein c-IAP2 (1). MALT1, along with the proteins CARMA1 and Bcl10 form an NF-kappaB-activating complex, termed the CBM signalsome, that acts downstream of lymphocyte antigen receptors as well as many other non-lymphoid cell-surface receptors that play a role in multiple cellular functions (2,3). MALT1 has proteolytic activity, and this activity is critical for full NF-kappaB response in T cell activation (4).

Molekulargewicht: Predicted: 91 kDa

Observed: 96 kDa

Gen-ID: 10892

NCBI Accession: NP_006776

UniProt: Q9UDY8

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine