PDGFRB Antikörper (AA 749-753)

Produktnummer ABIN5689529

Dieses Anti-PDGFRB-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PDGFRB in WB. Geeignet für Human, Maus und Ratte.

Kurzübersicht für PDGFRB Antikörper (AA 749-753) (ABIN5689529)

Target: PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDGFRB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PDGFRB Antikörper

Bindungsspezifität: AA 749-753

Spezifität: This antibody detects endogenous level of total PDGF Receptor β, protein.

Aufreinigung: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: PDGF Receptor beta (Ab-751) antibody was raised against a peptide sequence around aa.749~753 (V-D-Y-V-P) derived from Human PDGFRb.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1:500~1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store antibody at -20°C for up to one year.

Details zu PDGFRB

Target: PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))

Andere Bezeichnung: PDGF Receptor beta

Hintergrund: PDGF Receptor β, encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Molekulargewicht: 190 kDa

Gen-ID: 5159

NCBI Accession: NP_002600

UniProt: P09619

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling