PKM2 Antikörper (AA 405-409)

Produktnummer ABIN5689391

Dieses Anti-PKM2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PKM2 in WB. Geeignet für Human.

Kurzübersicht für PKM2 Antikörper (AA 405-409) (ABIN5689391)

Target: PKM2 (Pyruvate Kinase M2 (PKM2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PKM2 Antikörper

Bindungsspezifität: AA 405-409

Spezifität: This antibody detects endogenous levels of total PKM2 protein.

Aufreinigung: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: PKM2 antibody was raised against a peptide sequence around aa.405~409 (T-S-D-P-T) derived from Human PKM2.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1:500~1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store antibody at -20°C for up to one year.

Details zu PKM2

Target: PKM2 (Pyruvate Kinase M2 (PKM2))

Andere Bezeichnung: PKM2

Hintergrund: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Molekulargewicht: 60 kDa

Gen-ID: 5315

NCBI Accession: NP_872270

Pathways: Warburg Effekt