PLK1 Antikörper (pThr210)
Kurzübersicht für PLK1 Antikörper (pThr210) (ABIN5688913)
Target
Alle PLK1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- pThr210
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Aufreinigung
- Affinity Purified
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Immunogen
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr210 of PLK1.
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Applikationshinweise
- The antibody has been directly tested for reactivity in Western blots in rat and human tissues. It is anticipated that the antibody will react with bovine, canine, mouse, non-human primate, Xenopus and Zebrafish tissues based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- 100 μLin 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- PLK1 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
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- PLK1 (Polo-Like Kinase 1 (PLK1))
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Andere Bezeichnung
- PLK1
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Hintergrund
- Polo-like kinases are important regulators of cell cycle progression. PLK1 is a highly conserved Ser/Thr kinase that has essential roles in the formation of mitotic bipolar spindles (van Vugt et al., 2004). Deregulated expression of PLK's is detected in many types of cancer and associated with oncogenesis (Takei et al., 2005). It has been proposed that PLK1 function is altered at different stages of mitosis through consecutive phosphorylation events at Ser137 and Thr210 (van de Weerdt et al., 2005).
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Molekulargewicht
- 66 kDa
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Gen-ID
- 5347
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UniProt
- P53350
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Pathways
- Zellzyklus, M Phase
Target
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