Connexin 43/GJA1 Antikörper (pSer368)

Produktnummer ABIN5688898

Der Kaninchen Polyklonal Anti-Connexin 43/GJA1-Antikörper wurde für WB validiert. Er ist geeignet, Connexin 43/GJA1 in Proben von Human, Ratte, Maus, Hund, Rind (Kuh), Huhn, Zebrafisch (Danio rerio) und Ziege zu detektieren.

Kurzübersicht für Connexin 43/GJA1 Antikörper (pSer368) (ABIN5688898)

Target: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Huhn, Zebrafisch (Danio rerio), Ziege

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Connexin 43/GJA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Connexin 43/GJA1 Antikörper

Bindungsspezifität: pSer368

Aufreinigung: Affinity Purified

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser368 of rat connexin 43.

Anwendungsinformationen

Applikationshinweise: The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, chicken, guinea pig, human, mouse and zebra fish based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.

Lagerung: -20 °C

Informationen zur Lagerung: Connexin 43 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Details zu Connexin 43/GJA1

Target: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Andere Bezeichnung: Connexin 43

Hintergrund: Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin 43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin 43 is known to be regulated by phosphorylation at Ser368 by protein kinase C (Yogo et al., 2002, Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin 43 that results in a decrease in gap junction permeability (Bao et al., 2004b).

Molekulargewicht: 43 kDa

Gen-ID: 24392

UniProt: P08050

Pathways: MAPK Signalweg, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization