TIGIT Antikörper (Extracellular Domain)

Produktnummer ABIN5688740

Dieses Anti-TIGIT-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von TIGIT in ELISA, FACS, ICC, IF und IHC (p). Geeignet für Human.

Kurzübersicht für TIGIT Antikörper (Extracellular Domain) (ABIN5688740)

Target: TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TIGIT Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 7A5

Produktdetails anti-TIGIT Antikörper

Bindungsspezifität: Extracellular Domain

Aufreinigung: TIGIT Antibody is supplied as protein A purified IgG2b.

Immunogen: TIGIT antibody was raised against the extracellular domain of human TIGIT.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: TIGIT antibody can be used for immunohistochemistry starting at 2 - 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TIGIT Antibody is supplied in PBS containing 0.02% sodium azide and 50 % glycerol rather

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: TIGIT antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TIGIT

Target: TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))

Andere Bezeichnung: TIGIT

Hintergrund: TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity, this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).

Molekulargewicht: Predicted: 26 kDa

Gen-ID: 201633

NCBI Accession: NP_776160

UniProt: Q495A1

Pathways: Cancer Immune Checkpoints