PIK3R1 Antikörper

Produktnummer ABIN5557518

Dieser Maus Monoklonal Antikörper detektiert spezifisch PIK3R1 in WB, IF, IHC (p), ICC und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für PIK3R1 Antikörper (ABIN5557518)

Target: PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PIK3R1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 9B3

Produktdetails anti-PIK3R1 Antikörper

Verwendungszweck: PIK3R1 Monoclonal Antibody

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: Recombinant human PI3-kinase p85 subunit alpha protein, around 600-700aa.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB(1:500-2000), IHC-P(1:100-500), IHC-F(1:100-500), IF(1:100-500), ICC/IF(1:50-100)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu PIK3R1

Target: PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))

Andere Bezeichnung: PIK3R1

Hintergrund:

Synonyms: Phosphatidylinositol 3-kinase regulatory subunit alpha, PIK3R1, PI3-kinase regulatory subunit alpha, PI3K regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, PIK3R1, GRB1, PI3-kinase subunit p85-alpha, PtdIns-3-kinase regulatory subunit p85-alpha

Background: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p11 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.

Gen-ID: 5295

UniProt: P27986

Pathways: T-Zell Rezeptor Signalweg, Response to Growth Hormone Stimulus, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Hepatitis C, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling, Warburg Effekt