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Kdm6b Antikörper (N-Term)

Kdm6b Reaktivität: Human WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5551987
  • Target Alle Kdm6b Antikörper anzeigen
    Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))
    Bindungsspezifität
    • 12
    • 11
    • 6
    • 6
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 50
    • 23
    • 7
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Human
    Wirt
    • 54
    • 1
    • 1
    Kaninchen
    Klonalität
    • 55
    • 1
    Polyklonal
    Konjugat
    • 29
    • 6
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Kdm6b Antikörper ist unkonjugiert
    Applikation
    • 44
    • 31
    • 15
    • 11
    • 6
    • 4
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody will recognize JMJD3 (N-term).
    Aufreinigung
    Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human JMJD3.
    Isotyp
    Ig Fraction
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    Discover our top product Kdm6b Primärantikörper
  • Applikationshinweise
    ELISA: 1/1,000. Western Blot: 1/250-1/500. Immunohistochemistry: 1/10-1/50.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    PBS containing 0.09 % (W/V) Sodium Azide as preservative.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))
    Andere Bezeichnung
    JMJD3 / KDM6B (Kdm6b Produkte)
    Synonyme
    jmjd3 antikoerper, kdm6b antikoerper, si:ch211-237l4.7 antikoerper, 1700064E03Rik antikoerper, BC038313 antikoerper, Jmjd3 antikoerper, mKIAA0346 antikoerper, JMJD3 antikoerper, lysine (K)-specific demethylase 6B antikoerper, lysine demethylase 6B antikoerper, lysine (K)-specific demethylase 6B, b antikoerper, KDM1 lysine (K)-specific demethylase 6B antikoerper, kdm6b antikoerper, KDM6B antikoerper, kdm6bb antikoerper, Kdm6b antikoerper
    Hintergrund
    Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.Synonyms: Histone demethylase JMJD3, JmjC domain-containing protein 3, Jumonji domain-containing protein 3, KIAA0346, Lysine demethylase 6B
    Gen-ID
    23135, 9606
    UniProt
    O15054
    Pathways
    Warburg Effekt
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