Kdm6b Antikörper (C-Term)

Produktnummer ABIN387863

Es sind 5+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-Kdm6b Antikörper wird verwendet zum Nachweis von Kdm6b in Proben von Maus. Er wurde validiert für WB und IHC (p).

Kurzübersicht für Kdm6b Antikörper (C-Term) (ABIN387863)

Target: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Kdm6b Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB10081-RB10082

Produktdetails anti-Kdm6b Antikörper

Bindungsspezifität: AA 1606-1641, C-Term

Homologie: H

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse JMJD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1606-1641 amino acids from the C-terminal region of mouse JMJD3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Haltbarkeit: 6 months

Referenzen für anti-Kdm6b Antikörper (ABIN387863)

Pham, Yu, Walline, Muthukrishnan, Blum, Kaplan: "Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 2, pp. 902-11, (2013) (PubMed).

Das, Jung, Choi, Yoon, Kim, Chai: "Gene networking and inflammatory pathway analysis in a JMJD3 knockdown human monocytic cell line." in: Cell biochemistry and function, Vol. 30, Issue 3, pp. 224-32, (2012) (PubMed).

Solá, Xavier, Santos, Aranha, Morgado, Jepsen, Rodrigues: "p53 interaction with JMJD3 results in its nuclear distribution during mouse neural stem cell differentiation." in: PLoS ONE, Vol. 6, Issue 3, pp. e18421, (2011) (PubMed).

McLaughlin-Drubin, Crum, Münger: "Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 5, pp. 2130-5, (2011) (PubMed).

Das, Jung, Chai: "The role of NF-kappaB and H3K27me3 demethylase, Jmjd3, on the anthrax lethal toxin tolerance of RAW 264.7 cells." in: PLoS ONE, Vol. 5, Issue 3, pp. e9913, (2010) (PubMed).

Details zu Kdm6b

Target: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Andere Bezeichnung: JMJD3

Hintergrund: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

Molekulargewicht: 176355

Gen-ID: 216850

NCBI Accession: NP_001017426

UniProt: Q5NCY0

Pathways: Warburg Effekt