c-MET Antikörper

Produktnummer ABIN5542211

Dieser Ratte Monoklonal Antikörper detektiert spezifisch c-MET in FACS und EIA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für c-MET Antikörper (ABIN5542211)

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser c-MET Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Klon: BCI-3E7

Produktdetails anti-c-MET Antikörper

Spezifität: Recognizes c-Met. Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells.

Aufreinigung: Affinity Chromatography on Protein G

Immunogen: cDNA encoding Human c-Met

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 1.2 μg/10 6 cells. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.2

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu c-MET

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Andere Bezeichnung: hgf receptor

Hintergrund: C-MET is a receptor tyrosine kinase that is activated upon Hepatocyte Growth Factor (HGF) binding. c-MET is produced as a single-chain precursor and plays en essential role in embryonic development and wound healing. It belongs to the class of Singlepass type I membrane proteins and it is normally expressed by cells of epithelial origin while the expression of HGF is restricted to cells of mesenchymal origin in an almost perfect paracrine paradigm. Overexpression of c-MET can be found in several kinds of tumor progression.

UniProt: P08581

Pathways: RTK Signalweg, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor