PD-1 Antikörper

Produktnummer ABIN5540157

Der Maus Monoklonal anti-PD-1 Antikörper wird verwendet zum Nachweis von PD-1 in Proben von Human. Er wurde validiert für WB und EIA.

Kurzübersicht für PD-1 Antikörper (ABIN5540157)

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PD-1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Klon: 1C4

Produktdetails anti-PD-1 Antikörper

Spezifität: Reactive with recombinant Human Programmed Cell Death-1 (PD-1). Reactivity with natural PD-1 has not been evaluated.

Aufreinigung: Affinity Chromatography on Protein G

Immunogen: 40kDa recombinant Human Programmed Cell Death-1 (PD-1).

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Indirect ELISA. Western Blot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.01M PBS, pH 7.2 without preservatives

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Andere Bezeichnung: cd279,pd1

Hintergrund: Programmed Cell Death-1 (PD-1), also called CD279, is a 288 amino acid cell surface protein that belongs to the immunoglobulin superfamily. The protein is expressed on T cells, B cells and macrophages. When PD-1 is joined with its ligand (CD274 or B7-H1), the immune cell's activation and effector function are attenuated. Research suggested that PD1 pathway is mainly involved with attenuation at periphery sites while the B7/CTLA-4 pathway is primarily involved with the attenuation of the activation of immune cells in secondary lymphoid organs. PD-1 pathway is implicated with cancer's immune-evasion, autoimmunity, and Listeria monocytogenes infection.

UniProt: Q15116

Pathways: Cancer Immune Checkpoints