CDK8 Antikörper (AA 245-272)

Produktnummer ABIN5532872

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CDK8 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für CDK8 Antikörper (AA 245-272) (ABIN5532872)

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CDK8 Antikörper

Bindungsspezifität: AA 245-272

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Cdk8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-272 amino acids from the Central region of mouse Cdk8.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu CDK8

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Andere Bezeichnung: Cdk8

Hintergrund: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation (By similarity).

Molekulargewicht: 53 kDa

Gen-ID: 264064

UniProt: Q8R3L8

Pathways: Zellzyklus, Regulation of Lipid Metabolism by PPARalpha