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JAK1 Antikörper (N-Term)

Der Kaninchen Polyklonal Anti-JAK1-Antikörper wurde für WB validiert. Er ist geeignet, JAK1 in Proben von Human, Maus und Ratte zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN5518768

Kurzübersicht für JAK1 Antikörper (N-Term) (ABIN5518768)

Target

Alle JAK1 Antikörper anzeigen
JAK1 (Janus Kinase 1 (JAK1))

Reaktivität

  • 104
  • 80
  • 58
  • 3
  • 3
  • 2
  • 2
  • 1
Human, Maus, Ratte

Wirt

  • 82
  • 28
  • 1
  • 1
Kaninchen

Klonalität

  • 78
  • 34
Polyklonal

Konjugat

  • 61
  • 6
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser JAK1 Antikörper ist unkonjugiert

Applikation

  • 82
  • 35
  • 31
  • 16
  • 16
  • 16
  • 14
  • 12
  • 11
  • 10
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 17
    • 17
    • 8
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 78-115, N-Term

    Verwendungszweck

    Anti-JAK1 Antibody Picoband®

    Sequenz

    FALYDENTKL WYAPNRTITV DDKMSLRLHY RMRFYFTN

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-JAK1 Antibody Picoband® (ABIN5518768). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the N-terminus of human JAK1, different from the related mouse sequence by three amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    1. Gadina M, Hilton D, Johnston JA, Morinobu A, Lighvani A, Zhou YJ, Visconti R, O'Shea JJ (2001). "Signaling by type I and II cytokine receptors: ten years after". 2. Gough, N. M., Rakar, S., Harpur, A., Wilks, A. F. Localization of genes for two members of the JAK family of protein tyrosine kinases to murine chromosomes 4 and 19. Mammalian Genome 6: 247-248, 1995. 3. Howard, O. M. Z., Dean, M., Young, H., Ramsburg, M., Turpin, J. A., Michiel, D. F., Kelvin, D. J., Lee, L., Farrar, W. L. Characterization of a class 3 tyrosine kinase. Oncogene 7: 895-900, 1992.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Liu, Li, Liang, Li, Jiang, Chu, Yang: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, (2018) (PubMed).

  • Target

    JAK1 (Janus Kinase 1 (JAK1))

    Andere Bezeichnung

    JAK1

    Hintergrund

    Synonyms: Tyrosine-protein kinase JAK1,2.7.10.2,Janus kinase 1,JAK-1,JAK1,JAK1A, JAK1B,

    Tissue Specificity: Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. .

    Background: JAK1 (JANUS KINASE 1) is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It is a member of a new class of PTKs that are a large family of proteins characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain--hence the name Janus. The JAK1 gene is mapped to 1p31.3. JAK1 is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors. Additionally, Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.

    Molekulargewicht

    133 kDa

    Gen-ID

    3716

    UniProt

    P23458

    Pathways

    JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response
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