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EPAS1 Antikörper (Middle Region)

EPAS1 Reaktivität: Human, Maus, Ratte WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5518650
  • Target Alle EPAS1 Antikörper anzeigen
    EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
    Bindungsspezifität
    • 16
    • 11
    • 9
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 282-301, Middle Region
    Reaktivität
    • 92
    • 48
    • 42
    • 18
    • 17
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 100
    • 11
    • 1
    • 1
    Kaninchen
    Klonalität
    • 92
    • 21
    Polyklonal
    Konjugat
    • 57
    • 14
    • 7
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser EPAS1 Antikörper ist unkonjugiert
    Applikation
    • 92
    • 47
    • 32
    • 24
    • 15
    • 14
    • 14
    • 13
    • 13
    • 12
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Verwendungszweck
    Rabbit IgG polyclonal antibody for Endothelial PAS domain-containing protein 1(EPAS1) detection. Tested with WB in Human,Mouse,Rat.
    Sequenz
    HALDSENMTK SHQNLCTKGQ
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for Endothelial PAS domain-containing protein 1(EPAS1) detection. Tested with WB in Human,Mouse,Rat.
    Gene Name: endothelial PAS domain protein 1
    Protein Name: Endothelial PAS domain-containing protein 1(EPAS-1)
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence in the middle region of human HIF-2-alpha(282-301aa, HALDSENMTKSHQNLCTKGQ), identical to the related mouse and rat sequence.
    Isotyp
    IgG
    Top Product
    Discover our top product EPAS1 Primärantikörper
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide, Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Lu, Shi, Ma, Wang, Liu, Chuai, Song, Münsterberg, Cao, Yang: "Proper autophagy is indispensable for angiogenesis during chick embryo development." in: Cell cycle (Georgetown, Tex.), Vol. 15, Issue 13, pp. 1742-54, (2017) (PubMed).

  • Target
    EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
    Andere Bezeichnung
    EPAS1 (EPAS1 Produkte)
    Synonyme
    EPAS1 antikoerper, ECYT4 antikoerper, HIF2A antikoerper, HLF antikoerper, MOP2 antikoerper, PASD2 antikoerper, bHLHe73 antikoerper, HIF-2alpha antikoerper, HRF antikoerper, Hif2a antikoerper, bhlhe73 antikoerper, ecyt4 antikoerper, hif2 antikoerper, hif2a antikoerper, hif2alpha antikoerper, hlf antikoerper, mop2 antikoerper, pasd2 antikoerper, EPAS antikoerper, EPAS-1 antikoerper, endothelial PAS domain protein 1 antikoerper, endothelial PAS domain protein 1 L homeolog antikoerper, EPAS1 antikoerper, epas1 antikoerper, Epas1 antikoerper, epas1.L antikoerper
    Hintergrund
    HIF-2 alpha is also designated EPAS1 whose gene is mapped to 2p21-p16. The predicted mouse protein is 88 % identical to human EPAS1. The human EPAS1 gene contains 15 exons and spans at least 120 kb. The positions of the introns within the genomic region encoding the N-terminal bHLH-PAS domains of EPAS1 and AHR are similar, suggesting that the 5-prime ends of the 2 genes may have arisen from a gene duplication event1. Moreover, the predicted protein shares 48 % sequence identity with HIF1-alpha, a bHLH-PAS transcription factor that induces EPO gene expression in cultured cells in response to hypoxia. Like HIF1A, EPAS1 binds to and activates transcription from the HIF1A response element derived from the 3-prime flanking region of the EPO gene. EPAS1 is predominantly expressed in highly vascularized tissues of adult humans and in endothelial cells of the mouse adult and embryo. Furthermore, EPAS1 may represent an important regulator of vascularization, perhaps involving the regulation of endothelial cell gene expression in response to hypoxia2. HIF2A is expressed at relatively higher levels in villus sections of placenta and in lung samples compared with other tissues examined3. In addition, The variation in EPAS1 influences the relative contribution of aerobic and anaerobic metabolism and hence the maximum sustainable metabolic power for a given event duration4.

    Synonyms: Basic helix loop helix PAS protein MOP2 antibody|Basic-helix-loop-helix-PAS protein MOP2 antibody|bHLHe73 antibody|Class E basic helix-loop-helix protein 73 antibody|ECYT4 antibody|Endothelial PAS domain containing protein 1 antibody|Endothelial pas domain protein 1 antibody|Endothelial PAS domain-containing protein 1 antibody|EPAS 1 antibody|EPAS-1 antibody|EPAS1 antibody|EPAS1_HUMAN antibody|HIF 1 alpha like factor antibody|HIF 2 alpha antibody|HIF-1-alpha-like factor antibody|HIF-2-alpha antibody|HIF2-alpha antibody|Hif2a antibody|HLF antibody|Hypoxia inducible factor 2 alpha antibody|Hypoxia inducible factor 2 alpha subunit antibody|Hypoxia-inducible factor 2-alpha antibody|Member of PAS protein 2 antibody|Member of pas superfamily 2 antibody|MOP 2 antibody|MOP2 antibody|PAS domain-containing protein 2 antibody|PASD2 antibody
    UniProt
    Q99814
    Pathways
    Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effekt
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