TRIM29 Antikörper (AA 2-291)

Produktnummer ABIN5027599

Der Maus Monoklonal Anti-TRIM29-Antikörper wurde für WB und IHC validiert. Er ist geeignet, TRIM29 in Proben von Human zu detektieren.

Kurzübersicht für TRIM29 Antikörper (AA 2-291) (ABIN5027599)

Target: TRIM29 (Tripartite Motif Containing 29 (TRIM29))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TRIM29 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: ABM43D2

Produktdetails anti-TRIM29 Antikörper

Bindungsspezifität: AA 2-291

Aufreinigung: Protein G Chromatography

Immunogen: A partial length recombinant Trim29 protein (amino acids 2-291) was used as the immunogen for this antibody.

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL, IHC: 1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu TRIM29

Target: TRIM29 (Tripartite Motif Containing 29 (TRIM29))

Andere Bezeichnung: Trim29

Hintergrund: TRIM29 (Tripartite motif-containing 29) is a member of the tripartite motif (TRIM) family of transcription factors, characterized by the conserved RING finger, B-box, and coiled-coil domains. The TRIM family has been implicated in a variety of physiologic processes including development, apoptosis and epithelial-mesenchymal transition (EMT). Depending on a tumor types, TRIM29 also may function as an oncogene or a tumor suppressor. As an oncogene, it facilitates tumor cell proliferation and invasion through stabilization of Beta-catenin. The mechanisms may also involve deactivation of p53 activity and promoting cell survival by inhibiting proapoptotic genes regulated by p53. As a histone binding protein TRIM29 is responsible for DDR (DNA damage response). It functions as a scaffold protein to assemble DNA repair proteins into chromatin followed by efficient activation of DDR. TRIM29 binds to modified histone H3 and H4 tails in the context of nucleosomes. Furthermore, chromatin binding of TRIM29 is required for the phosphorylation of H2AX nucleosomes and cell viability in response to ionizing radiation.

Molekulargewicht: 65 kDa

Gen-ID: 23650

UniProt: Q14134

Pathways: p53 Signalweg, Apoptose, DNA Reparatur, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus