TLR10 Antikörper (AA 100-369)

Produktnummer ABIN5027569

Produktdetails anti-TLR10 Antikörper

Target: TLR10 (Toll-Like Receptor 10 (TLR10))

Bindungsspezifität: AA 100-369

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TLR10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Protein G Chromatography

Immunogen: A partial length recombinant TLR10 protein (amino acids 100-369) was used as the immunogen for this antibody.

Klon: ABM3C85

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu TLR10

Target: TLR10 (Toll-Like Receptor 10 (TLR10))

Andere Bezeichnung: TLR10 (TLR10 Produkte)

Synonyme: TLR10 antikoerper, CD290 antikoerper, toll like receptor 10 antikoerper, toll-like receptor 10 antikoerper, TLR10 antikoerper, Tlr10 antikoerper

Hintergrund: TLR10 (Toll-Like Receptor10) is an orphan member of the TLR family and is the only pattern-recognition receptor without known ligand specificity and biological function. This protein plays a role in innate immune responses following viral infection. Influenza virus infection increased TLR10 expression and TLR10 contributed to innate immune sensing of viral infection leading to cytokine induction, including proinflammatory cytokines and interferons. Blocking TLR10 by antagonistic antibodies enhanced proinflammatory cytokine production, including IL-1Beta, specifically after exposure to TLR2 ligands. TLR10 is in a locus that also contains TLR1 and TLR6, two receptors known to function as coreceptors for TLR2. TLR10 is predominantly expressed in tissues rich in immune cells, such as spleen, lymph node, thymus, tonsil, and lung. Expression of TLR10 can be induced in B cells, dendritic cells, eosinophils, and neutrophils, as well as on nonimmune cells, such as trophoblasts.

Molekulargewicht: 116 kDa

Gen-ID: 81793

UniProt: Q9BXR5

Pathways: TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades