UNC93B1 Antikörper (N-Term)

Produktnummer ABIN501104

Der Kaninchen Polyklonal Anti-UNC93B1-Antikörper wurde für WB, IHC (p) und EIA validiert. Er ist geeignet, UNC93B1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für UNC93B1 Antikörper (N-Term) (ABIN501104)

Target: UNC93B1 (Unc-93 Homolog B1 (UNC93B1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UNC93B1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-UNC93B1 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody detects Unc93b. The antibody will not cross-react with Unc93a.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography

Immunogen: Unc93b antibody was raised against a 19 amino acid peptide from near the amino terminus of human Unc93b.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu UNC93B1

Target: UNC93B1 (Unc-93 Homolog B1 (UNC93B1))

Andere Bezeichnung: UNC93B1

Hintergrund: The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9, the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity. Multiple isoforms of Unc93a are known to exist.Synonyms: Protein unc-93 homolog B1, UNC-93B, UNC93

Gen-ID: 81622

NCBI Accession: NP_112192

Pathways: TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades