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NOD2 Antikörper (C-Term)

NOD2 Reaktivität: Human WB, IF, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500365
  • Target Alle NOD2 Antikörper anzeigen
    NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))
    Bindungsspezifität
    • 16
    • 5
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    C-Term
    Reaktivität
    • 38
    • 5
    • 4
    Human
    Wirt
    • 37
    • 3
    • 1
    Kaninchen
    Klonalität
    • 39
    • 2
    Polyklonal
    Konjugat
    • 20
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NOD2 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 17
    • 14
    • 8
    • 7
    • 6
    • 6
    • 4
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Spezifität
    This antiobody detects CARD15 / NOD2 at C-term. It has no cross-reaction with NOD1.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    Rabbit NOD2 polyclonal antibody was raised against a synthetic peptide corresponding to 14 amino acids at the carboxy terminus of human NOD2.
    Isotyp
    IgG
    Top Product
    Discover our top product NOD2 Primärantikörper
  • Applikationshinweise
    ELISA. Western blot: 2 - 4 μg/mL. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))
    Andere Bezeichnung
    CARD15 / NOD2 (NOD2 Produkte)
    Synonyme
    ACUG antikoerper, BLAU antikoerper, CARD15 antikoerper, CD antikoerper, CLR16.3 antikoerper, IBD1 antikoerper, NLRC2 antikoerper, NOD2B antikoerper, PSORAS1 antikoerper, Card15 antikoerper, F830032C23Rik antikoerper, Nlrc2 antikoerper, caspase recruitment domain 15 protein antikoerper, nucleotide binding oligomerization domain containing 2 antikoerper, nucleotide-binding oligomerization domain containing 2 antikoerper, TTHERM_01951320 antikoerper, NOD2 antikoerper, Nod2 antikoerper
    Hintergrund
    Apaf-1 and NOD1 are members of a new family (1), which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD). A third member in this family was recently identified and designated NOD2 (2). NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-κB, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn's disease (3,4) that is a main type of chronic inflammatory bowel disease.Synonyms: Caspase recruitment domain-containing protein 15, IBD1, Inflammatory bowel disease protein 1, Nucleotide-binding oligomerization domain-containing protein 2
    Gen-ID
    64127
    UniProt
    Q9HC29
    Pathways
    Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome
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