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Complement C4 Antikörper (AA 21-120) (AbBy Fluor® 680)

Der Kaninchen Polyklonal Anti-Complement C4-Antikörper wurde für IF (p) und IF (cc) validiert. Er ist geeignet, Complement C4 in Proben von Human zu detektieren.
Produktnummer ABIN5000362

Kurzübersicht für Complement C4 Antikörper (AA 21-120) (AbBy Fluor® 680) (ABIN5000362)

Target

Alle Complement C4 (C4) Antikörper anzeigen
Complement C4 (C4) (Complement 4 (C4))

Reaktivität

  • 51
  • 6
  • 5
  • 1
Human

Wirt

  • 48
  • 6
  • 5
  • 3
  • 1
Kaninchen

Klonalität

  • 54
  • 9
Polyklonal

Konjugat

  • 30
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Dieser Complement C4 Antikörper ist konjugiert mit AbBy Fluor® 680

Applikation

  • 25
  • 25
  • 19
  • 16
  • 12
  • 12
  • 10
  • 8
  • 6
  • 5
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
  • Bindungsspezifität

    • 15
    • 14
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 21-120

    Homologie

    Human

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human Complement C4

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    Complement C4 (C4) (Complement 4 (C4))

    Andere Bezeichnung

    Complement C4

    Hintergrund

    Synonyms: C4, RG, C4S, CO4, C4A2, C4A3, C4A4, C4A6, C4AD, CPAMD2, CH, C4F, C4B1, C4B2, C4B3, C4B5, C4BD, C4B12, C4B_2, CPAMD3, Complement C4-A, Acidic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, C4A

    Background: Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

    Gen-ID

    720, 721

    UniProt

    P0C0L4

    Pathways

    Komplementsystem
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