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Complement C4 Antikörper (Complement 4) Primary Antibody

C4 Reaktivität: Maus IHC (fro), WB Wirt: Ratte Monoclonal 16D2 unconjugated
Pubmed (2 Referenzen)
Produktnummer ABIN2191789
$729.45
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle Complement C4 (C4) Antikörper anzeigen
    Complement C4 (C4)
    Reaktivität
    • 58
    • 5
    • 4
    • 1
    Maus
    Wirt
    • 48
    • 8
    • 5
    • 3
    • 2
    • 2
    Ratte
    Klonalität
    • 61
    • 7
    Monoklonal
    Konjugat
    • 34
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Dieser Complement C4 Antikörper ist unkonjugiert
    Applikation
    • 26
    • 26
    • 19
    • 13
    • 13
    • 11
    • 9
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
    Kreuzreaktivität (Details)
    Cross reactivity: C4b : Yes, C4d : Yes
    Sterilität
    0.2 μm filtered
    Klon
    16D2
    Isotyp
    IgG2a
  • Applikationshinweise
    For immunohistochemistry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Positive T-cell regions of mouse spleen control
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Murata, Fox-Talbot, Qian, Takahashi, Stahl, Baldwin, Wasowska: "Synergistic deposition of C4d by complement-activating and non-activating antibodies in cardiac transplants." in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 7, Issue 11, pp. 2605-14, (2007) (PubMed).

    Paul, Pozdnyakova, Mitchell, Carroll: "Anti-DNA autoreactivity in C4-deficient mice." in: European journal of immunology, Vol. 32, Issue 9, pp. 2672-9, (2002) (PubMed).

  • Target
    Complement C4 (C4)
    Andere Bezeichnung
    c4 (C4 Produkte)
    Synonyme
    C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4B_2, C4F, CH, CO4, CPAMD3, C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CPAMD2, RG, C4-1, C4b, C4-2, Slp, Ss, complement C4B (Chido blood group), complement C4A (Rodgers blood group), complement component 4A (Rodgers blood group), complement 4, complement component 4A, complement component 4B (Chido blood group), C4B, C4A, C4a, C4, C4b
    Hintergrund
    The monoclonal antibody 16D2 recognizes mouse complement factor C4, formerly known as Gg protein, which consists of an alpha-, beta-, and gamma-chain. The classical pathway of complement and the Mannose binding lectin activation pathway converge at C4. C1s, MASP-1 and MASP-2 cleave C4 resulting in the formation of C4a and C4b. Subsequently, C4b can be cleaved to C4c and C4d by other serum enzymes. The monoclonal antibody 16D2 reacts with intact C4, C4b and C4d. C4 is an acute phase protein that is produced by hepatocytes, monocytes and intestinal epithelial cells and can be used in experimental animals as a marker for activation of the classical complement pathway. Recent studies have demonstrated an association between graft rejection and C4d deposition in a mouse model for cardiac transplantation. Aliases Complement component 4 Immunogen Thymocytes decorated with Thy-1 antibody and complement components
    Pathways
    Komplementsystem
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