Paxillin Antikörper (pTyr31)

Produktnummer ABIN498711

Produktdetails anti-Paxillin Antikörper

Target: Paxillin (PXN)

Bindungsspezifität: pTyr31

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Paxillin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of p-Paxillin protein, only when phosphorylated at Tyr31.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Paxillin

Target: Paxillin (PXN)

Andere Bezeichnung: Paxillin / PXN (PXN Produkte)

Synonyme: AW108311 antikoerper, AW123232 antikoerper, Pax antikoerper, CG18061 antikoerper, CG18576 antikoerper, CG31794 antikoerper, CT40481 antikoerper, CT42454 antikoerper, DPaxillin antikoerper, DPxn antikoerper, DPxn37 antikoerper, Dmel\\CG31794 antikoerper, Dpax antikoerper, DpaxA antikoerper, PDLP antikoerper, dPax antikoerper, pax antikoerper, wu:fw71f12 antikoerper, PXN antikoerper, LOC100220858 antikoerper, paxillin antikoerper, Paxillin antikoerper, paxillin S homeolog antikoerper, paxillin a antikoerper, PXN antikoerper, Pxn antikoerper, Pax antikoerper, pxn.S antikoerper, pxna antikoerper, LOC696336 antikoerper, pxn antikoerper

Hintergrund: The effects of some oncogenes, growth factors and neuropeptides are mediated by tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin cytoskeletal proteins. A rapid increase in tyrosine phosphorylation of paxillin, FAK and Crk-associated substrate (CAS) are prominent early events triggered by many G protein-coupled receptors. In addition to G protein-coupled receptors, Angiotensin IV (Ang IV), protein kinase C and other proteins can also mediate the tyrosine phosphorylation of paxillin. Paxillin must bind FAK for maximal phosphorylation in response to cell adhesion. FAK may function to direct tyrosine phosphorylation of paxillin in the process of transformation by the Src oncogene.Synonyms: FLJ16691

Molekulargewicht: approx. 68 kDa

Gen-ID: 5829

NCBI Accession: NP_001074324

UniProt: P49023

Pathways: MAPK Signalweg, EGFR Signaling Pathway, Response to Growth Hormone Stimulus, Cell-Cell Junction Organization, Maintenance of Protein Location, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling