PDGFA Antikörper

Produktnummer ABIN498533

Produktdetails anti-PDGFA Antikörper

Target: PDGFA (Platelet Derived Growth Factor A (PDGFA))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDGFA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This detects endogenous levels of PDGF-A protein. (region surrounding Lys154)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography using epitope-specific immunogen

Reinheit: > 95 % (by SDS-PAGE)

Anwendungsinformationen

Applikationshinweise: Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu PDGFA

Target: PDGFA (Platelet Derived Growth Factor A (PDGFA))

Andere Bezeichnung: PDGFA (PDGFA Produkte)

Synonyme: PDGF-A antikoerper, PDGF1 antikoerper, pdgfa antikoerper, pdgfa-2 antikoerper, zgc:100777 antikoerper, pdgf antikoerper, pdgf1 antikoerper, pdgf-a antikoerper, AA409063 antikoerper, CD142 antikoerper, Cf-3 antikoerper, Cf3 antikoerper, TF antikoerper, PDGFACP antikoerper, wu:fc32c12 antikoerper, zgc:153249 antikoerper, platelet derived growth factor subunit A antikoerper, platelet-derived growth factor alpha polypeptide a antikoerper, coagulation factor III antikoerper, platelet derived growth factor, alpha antikoerper, platelet derived growth factor subunit A S homeolog antikoerper, platelet-derived growth factor alpha polypeptide b antikoerper, PDGFA antikoerper, pdgfaa antikoerper, pdgfa antikoerper, F3 antikoerper, Pdgfa antikoerper, pdgfa.S antikoerper, pdgfab antikoerper

Hintergrund: PDGF is a mitogen for mesenchyme- and glia-derived cells. It consists of two disulfide-bonded polypeptide chains, A and B, and occurs as three isoforms, PDGF-AA, PDGF-AB and PDGF-BB. The three isoforms bind with different affinities to two receptor types, α and β, which are structurally related and endowed with protein-tyrosine kinase domains. Ligand binding induces activation of the receptor kinases by formation of receptor dimers, the A subunit of PDGF binds only to α receptors with high affinity, whereas the B subunit can bind to both α and β receptors. Evidence suggests that PDGF may function as a neurotrophic factor. The fact that receptors for PDGF-A are expressed in oligodendrocyte progenitor cells whereas receptors for PDGF-B are expressed on neurons suggests that the different isoforms of PDGF may regulate growth and differentiation of different cell types in the developing central nervous system by paracrine and autocrine routes.Synonyms: PDGF A, PDGF alpha, PDGF subunit A, PDGF-1, PDGF-A, PDGF1, Platelet-derived growth factor A chain, Platelet-derived growth factor alpha, Platelet-derived growth factor subunit A

Molekulargewicht: approx. 21 kDa

Gen-ID: 5154

NCBI Accession: NP_002598

UniProt: P04085

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling