XBP1 Antikörper (AA 62-91)

Produktnummer ABIN3029642

Der Kaninchen Polyklonal Anti-XBP1-Antikörper wurde für WB, ELISA, IHC und FACS validiert. Er ist geeignet, XBP1 in Proben von Human zu detektieren.

Kurzübersicht für XBP1 Antikörper (AA 62-91) (ABIN3029642)

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-XBP1 Antikörper

Bindungsspezifität: AA 62-91

Kreuzreaktivität (Details): Expected species reactivity: Mouse, Rat, Bovine

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 62-91 from the human protein was used as the immunogen for this XBP1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the XBP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the XBP1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu XBP1

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Andere Bezeichnung: XBP1

Hintergrund: XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor.

UniProt: P17861

Pathways: ER-Nucleus Signaling, Unfolded Protein Response