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XBP1 Antikörper (AA 217-244)

XBP1 Reaktivität: Maus WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3029641
  • Target Alle XBP1 Antikörper anzeigen
    XBP1 (X-Box Binding Protein 1 (XBP1))
    Bindungsspezifität
    • 16
    • 11
    • 7
    • 7
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 217-244
    Reaktivität
    • 73
    • 38
    • 12
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    Maus
    Wirt
    • 69
    • 14
    • 1
    Kaninchen
    Klonalität
    • 68
    • 16
    Polyklonal
    Konjugat
    • 50
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser XBP1 Antikörper ist unkonjugiert
    Applikation
    • 70
    • 35
    • 25
    • 22
    • 14
    • 13
    • 13
    • 13
    • 10
    • 9
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), ELISA
    Aufreinigung
    Antigen affinity purified
    Immunogen
    A portion of amino acids 217-244 from the human protein was used as the immunogen for this XBP1 antibody.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product XBP1 Primärantikörper
  • Applikationshinweise
    Titration of the XBP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Aliquot the XBP1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    XBP1 (X-Box Binding Protein 1 (XBP1))
    Andere Bezeichnung
    XBP1 (XBP1 Produkte)
    Hintergrund
    This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
    UniProt
    P17861
    Pathways
    ER-Nucleus Signaling, Unfolded Protein Response
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