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XBP1 Antikörper (AA 217-244)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch XBP1 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Maus.
Produktnummer ABIN3029641

Kurzübersicht für XBP1 Antikörper (AA 217-244) (ABIN3029641)

Target

Alle XBP1 Antikörper anzeigen
XBP1 (X-Box Binding Protein 1 (XBP1))

Reaktivität

  • 73
  • 38
  • 12
  • 6
  • 6
  • 4
  • 3
  • 3
  • 2
  • 2
Maus

Wirt

  • 69
  • 14
  • 1
Kaninchen

Klonalität

  • 68
  • 16
Polyklonal

Konjugat

  • 50
  • 5
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser XBP1 Antikörper ist unkonjugiert

Applikation

  • 70
  • 35
  • 25
  • 22
  • 14
  • 13
  • 13
  • 13
  • 10
  • 9
  • 4
  • 3
  • 3
  • 1
Western Blotting (WB), ELISA
  • Bindungsspezifität

    • 16
    • 11
    • 7
    • 7
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 217-244

    Aufreinigung

    Antigen affinity purified

    Immunogen

    A portion of amino acids 217-244 from the human protein was used as the immunogen for this XBP1 antibody.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    Titration of the XBP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    In 1X PBS, pH 7.4, with 0.09 % sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Aliquot the XBP1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target

    XBP1 (X-Box Binding Protein 1 (XBP1))

    Andere Bezeichnung

    XBP1

    Hintergrund

    This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.

    UniProt

    P17861

    Pathways

    ER-Nucleus Signaling, Unfolded Protein Response
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