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FLT4 Antikörper

Der Maus Monoklonal Anti-FLT4-Antikörper wurde für WB, IHC, ELISA und FACS validiert. Er ist geeignet, FLT4 in Proben von Human zu detektieren.
Produktnummer ABIN3030977

Kurzübersicht für FLT4 Antikörper (ABIN3030977)

Target

Alle FLT4 Antikörper anzeigen
FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))

Reaktivität

  • 84
  • 55
  • 17
  • 12
Human

Wirt

  • 78
  • 28
  • 9
  • 2
  • 1
Maus

Klonalität

  • 79
  • 39
Monoklonal

Konjugat

  • 63
  • 12
  • 8
  • 6
  • 5
  • 4
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser FLT4 Antikörper ist unkonjugiert

Applikation

  • 62
  • 49
  • 41
  • 31
  • 19
  • 17
  • 14
  • 13
  • 13
  • 9
  • 7
  • 5
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Klon

818CT12-1-1
  • Aufreinigung

    Purified

    Immunogen

    Purified His-tagged protein was used to produced this monoclonal VEGFR3 antibody.

    Isotyp

    IgG2a
  • Applikationshinweise

    Titration of the VEGFR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Flow Cytometry: 1:25,IHC (Paraffin): 1:25,Western blot: 1:2000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    In 1X PBS, pH 7.4, with 0.09 % sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Aliquot the VEGFR3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target

    FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))

    Andere Bezeichnung

    VEGFR3

    Hintergrund

    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades, isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.

    UniProt

    P35916

    Pathways

    RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling
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