MECP2 Antikörper (pSer80)

Produktnummer ABIN3031767

Dieses Anti-MECP2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MECP2 in ELISA und DB. Geeignet für Human.

Kurzübersicht für MECP2 Antikörper (pSer80) (ABIN3031767)

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MECP2 Antikörper ist unkonjugiert

Applikation: ELISA, Dot Blot (DB)

Produktdetails anti-MECP2 Antikörper

Bindungsspezifität: pSer80

Kreuzreaktivität (Details): Expected species reactivity: Mouse, Rat, Primate

Aufreinigung: Antigen affinity purified

Immunogen: This phospho-MeCP2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS80 of human MeCP2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the phospho-MeCP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the phospho-MeCP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu MECP2

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Andere Bezeichnung: MeCP2

Hintergrund: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

UniProt: P51608

Pathways: Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane