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LIN28B Antikörper (AA 218-250)

Dieses Anti-LIN28B-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von LIN28B in WB, ELISA und FACS. Geeignet für Human.
Produktnummer ABIN3031629

Kurzübersicht für LIN28B Antikörper (AA 218-250) (ABIN3031629)

Target

Alle LIN28B Antikörper anzeigen
LIN28B (Lin-28 Homolog B (LIN28B))

Reaktivität

  • 48
  • 9
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 47
  • 1
  • 1
Kaninchen

Klonalität

  • 46
  • 3
Polyklonal

Konjugat

  • 33
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser LIN28B Antikörper ist unkonjugiert

Applikation

  • 33
  • 21
  • 20
  • 20
  • 18
  • 6
  • 6
  • 4
  • 4
  • 1
Western Blotting (WB), ELISA, Flow Cytometry (FACS)
  • Bindungsspezifität

    • 8
    • 6
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 218-250

    Aufreinigung

    Purified

    Immunogen

    A portion of amino acids 218-250 from the human protein was used as the immunogen for this LIN28B antibody.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    Titration of the LIN28B antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    In 1X PBS, pH 7.4, with 0.09 % sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Aliquot the LIN28B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target

    LIN28B (Lin-28 Homolog B (LIN28B))

    Andere Bezeichnung

    LIN28B

    Hintergrund

    Lin-28 homolog B (LIN28B) is overexpressed in hepatocellular carcinoma. The heterochronic gene lin-28 is a key regulator of developmental timing in the nematode Caenorhabditis elegans. Similar with lin-28 proteins, LIN28B conserves a cold shock domain and a pair of CCHC zinc finger domains. Phylogenetic analysis suggests that they might arise as a result of duplication from an ancestral gene. Overexpression of LIN28B was noted in most HCC cell lines and clinical samples. A short LIN28B isoform was also identified in non-tumor liver tissue and fetal liver. Although predominantly localized in the cytoplasm, LIN28B protein shows cell cycle-dependent nuclear translocation in Huh7 cells. Induced expression of exogenous LIN28B in a tet-off cell line promoted cancer cell proliferation.

    UniProt

    Q6ZN17
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