Kdm6b Antikörper (AA 954-987)

Produktnummer ABIN3031662

Dieses Anti-Kdm6b-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Kdm6b in WB und ELISA. Geeignet für Human und Maus.

Kurzübersicht für Kdm6b Antikörper (AA 954-987) (ABIN3031662)

Target: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Kdm6b Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Kdm6b Antikörper

Bindungsspezifität: AA 954-987

Aufreinigung: Purified

Immunogen: A portion of amino acids 954-987 from the mouse protein was used as the immunogen for this JMJD3 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the JMJD3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the JMJD3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu Kdm6b

Target: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Andere Bezeichnung: JMJD3 (KDM6B)

Hintergrund: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

UniProt: Q5NCY0

Pathways: Warburg Effekt