MAPK7 Antikörper (AA 776-805)

Produktnummer ABIN3031834

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MAPK7 in WB, IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für MAPK7 Antikörper (AA 776-805) (ABIN3031834)

Target: MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPK7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-MAPK7 Antikörper

Bindungsspezifität: AA 776-805

Kreuzreaktivität (Details): Expected species reactivity: Mouse, Rat, Bovine

Aufreinigung: Purified

Immunogen: A portion of amino acids 776-805 from the human protein was used as the immunogen for this ERK5 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the ERK5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the ERK5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu MAPK7

Target: MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))

Andere Bezeichnung: ERK5

Hintergrund: MEK5 and ERK5, a member of the MAP kinase subfamily of the Ser/Thr protein kinases, interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. ERK5 is activated by tyrosine and threonine phosphorylation It is expressed in many adult tissues, abundantly in heart, placenta, lung, kidney and skeletal muscle, but is not detectable in liver. The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell. ERK5 is autophosphorylated on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.

UniProt: Q13164

Pathways: MAPK Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, cAMP Metabolic Process, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling