MAP3K12 Antikörper

Produktnummer ABIN3031847

Produktdetails anti-MAP3K12 Antikörper

Target: MAP3K12 (Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP3K12 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Antigen affinity purified

Immunogen: This DLK antibody was produced from rabbits immunized with a recombinant protein of human DLK.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the DLK antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the DLK antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu MAP3K12

Target: MAP3K12 (Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12))

Andere Bezeichnung: DLK (MAP3K12 Produkte)

Synonyme: DLK antikoerper, MEKK12 antikoerper, MUK antikoerper, ZPK antikoerper, ZPKP1 antikoerper, PK antikoerper, Zpk antikoerper, zgc:77370 antikoerper, MGC151798 antikoerper, dlk antikoerper, map3k12 antikoerper, map3k12a antikoerper, mekk12 antikoerper, muk antikoerper, zpk antikoerper, zpkp1 antikoerper, DKFZp459K2433 antikoerper, map3k12-a antikoerper, map3k12-b antikoerper, map3k12b antikoerper, mitogen-activated protein kinase kinase kinase 12 antikoerper, mitogen activated protein kinase kinase kinase 12 antikoerper, mitogen-activated protein kinase kinase kinase 12 S homeolog antikoerper, mitogen-activated protein kinase kinase kinase 12 L homeolog antikoerper, MAP3K12 antikoerper, Map3k12 antikoerper, map3k12 antikoerper, map3k12.S antikoerper, map3k12.L antikoerper

Hintergrund: This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes, it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance, this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.

UniProt: P80370

Pathways: MAPK Signalweg